10 Best Cat Urine Removers 2025 in the United States

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator is a robust enzyme-based cleaner designed to tackle tough pet stains and odors, including cat urine. Its formula uses natural enzymes that break down urine and organic messes, making stains and smells disappear rather than just masking them. The scent is a clean 'original' fragrance, which is generally mild and not overpowering. This cleaner is safe to use on many surfaces, including carpets, floors, furniture, clothing, litter boxes, and pet carriers, making it very versatile for homes with pets.

The product is certified safe by the Carpet and Rug Institute, so it won’t damage colors or leave harmful residues, which is reassuring for households with kids or sensitive pets. It comes in a large 1-gallon bottle applied as a spray or drop, allowing easy treatment of affected areas. The formula is chlorine-free and eco-friendly, avoiding harsh chemicals and propellants, which makes it a safer choice for environmentally conscious users. Some users have mentioned the weight and size of the gallon bottle can be a bit bulky to handle.

This enzyme cleaner is a strong option for pet owners looking for a safe, effective, and multi-surface product to eliminate cat urine stains and odors without harmful chemicals. It has received many positive reviews endorsing its effectiveness.

Nature's Miracle Urine Destroyer Plus is designed to tackle severe cat urine stains using a powerful enzymatic formula that breaks down urine on contact and continues working as long as any residue remains. This makes it excellent for deep cleaning and odor removal. The large 1-gallon bottle is convenient for refilling smaller spray bottles, which is handy if you have multiple problem spots. It has a neutral odor labeled as 'Odor Remover,' so it doesn’t leave a strong fragrance behind, which is appreciated if you prefer scent-free cleaning.

The formula is safe to use around pets and home surfaces when used as directed. Application is straightforward—just pour or spray—but it is advisable to allow sufficient time for the product to work and dry before pets return to the area. This product works well for heavy stains and odor with a trusted enzymatic formula and large size, making it practical for homes with multiple cats.

Users should be mindful about testing on delicate surfaces before full application.

The ANGRY ORANGE Pet Odor Eliminator is a popular choice for pet owners dealing with stubborn odors from cat and dog urine. One of its strongest points is its enzyme-based formula, which effectively breaks down the sources of odors rather than just masking them. The pleasant citrus scent, derived from fresh orange peels, adds a refreshing aroma to your home, making it more inviting after cleaning. With no mixing required, this product is ready to use straight out of the bottle, making it convenient for quick applications.

This spray can be used on various surfaces, including carpets, upholstery, and even hard surfaces like tile and garbage cans, showcasing its versatility. Pet owners will appreciate that it doesn't require a lot of product for effective results, which can make it cost-efficient in the long run.

While the citrus scent is pleasant for many, it may not be suitable for pets like cats and birds, as they can be sensitive to certain ingredients. It's important to follow the instructions carefully, which suggest keeping pets away from the treated area until it is fully dry. Drying time is also something to consider; users may need to wait before allowing pets back into the cleaned area.