10 Best Cat Urine Enzymatic Cleaner 2025 in the United States

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a strong contender in the category of enzymatic cleaners for cat urine and other pet-related stains. Its enzyme formula is key to its effectiveness, as it works by breaking down odors and stains at a deep level, ensuring a thorough clean. This makes it particularly suitable for pet owners looking to tackle strong odors from urine, feces, or even vomit without harsh chemicals. One of its biggest advantages is that it's certified safe for use around pets and children, being chlorine-free and color-safe, which provides peace of mind when cleaning in family spaces.

Compatibility with various surfaces is another strong point; it can be used on carpets, floors, furniture, and other pet areas. This versatility is beneficial for pet owners who need a reliable cleaner for multiple surfaces. Additionally, the product is eco-friendly, appealing to those looking to minimize their environmental impact.

While the product has a lot of strengths, there are a few considerations. Some users may find that the drying time can vary, and while it's designed to eliminate both stains and odors, results can depend on the severity of the stain or the material being cleaned. Moreover, there are mixed experiences regarding its effectiveness on older, set-in stains, which may not be as easily resolved. Lastly, while the scent is described as 'original', some users may prefer a more fragrant option or find the scent not to their liking.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is a strong contender for anyone needing a versatile cleaner that handles tough organic stains and odors, including cat urine. Its enzyme formula uses probiotics that actively break down proteins, fats, and other organic matter for up to 21 days, which means it keeps working long after you apply it. This is particularly useful for stubborn pet stains that can hide in carpets or grout. The cleaner is safe on a variety of surfaces like floors, carpets, bathroom and kitchen areas, making it a flexible option for different household messes. It comes with a fresh lemon and sage scent that helps mask odors without being overpowering. Application is straightforward—you just spray and let it work, with no need for scrubbing.

Being biobased and free from harsh chemicals makes it an eco-friendly choice for pet owners looking for safer cleaning solutions. On the downside, because it’s a multipurpose cleaner, it might not be as specialized for cat urine as some dedicated enzymatic pet stain removers, which sometimes include additional stain-lifting agents. Also, the larger 1-gallon size is great for extensive use but might be bulky or more than needed for small households.

This cleaner offers a plant-based, probiotic-powered way to tackle pet odors and stains effectively across many surfaces, with the added benefit of a natural scent and lasting action.

The Angry Orange Pet Stain Remover is a versatile enzymatic cleaner designed to tackle the stubborn stains and odors left by cat urine, feces, and vomit. Its enzyme-active formula effectively breaks down organic materials, which is crucial for a true clean rather than just masking scents. This makes it a strong candidate for anyone dealing with persistent pet messes. Additionally, the product can be used on a wide range of surfaces including carpets, tile, hardwood, upholstery, and even car interiors, offering flexibility and convenience for various cleaning needs.

One of the appealing features is its fresh linen scent, which not only helps in eliminating odors but also leaves a pleasant fragrance behind. However, the scent might be a subjective matter, as some might prefer a neutral smell or worry about artificial fragrances. The spray form allows for precise application, but users should always follow the directions—such as shaking the bottle and removing excess mess first—to ensure the enzymes work effectively.

This product is particularly well-suited for pet owners looking for a multipurpose, effective cleaner that doesn't just mask odors, but actively neutralizes them, all while offering a pleasant scent and flexibility across different surfaces.