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10 Best Enzymatic Cleaners For Dog Urine 2025 in the United States

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Our Top Picks

#1

Winner

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

Rating
9.7
Chosen by1,273
Surface Compatibility
Scent

Most important from
119423 reviews

Surface Compatibility
I have also used it on just about every type of material; hardwood, wooden chests, carpet, clothing, couch fabric, cabinets, outside - none of the areas that I have used this cleaner on have stained or look any different condition wise than they looked before I used it!
Scent
The smell of the spray itself isn't offending at all either, it doesn't smell like chemicals at all and after a few hours you don't even notice that you even sprayed it - it just smells like your house again.

The Rocco & Roxie Supply Co. Stain & Odor Eliminator is a versatile enzymatic cleaner designed to tackle strong odors and stains from pet accidents. This product stands out because it is certified safe and gentle, making it ideal for use around pets and children. The enzyme-activated formula effectively breaks down ammonia crystals and organic matter, ensuring thorough removal of pet urine, feces, vomit, and other spills.

Its compatibility with a wide range of surfaces, including carpets, floors, furniture, and even clothing, adds to its convenience. Additionally, the lack of chlorine and color-safe properties means it won’t leave any harmful residues behind, which is a significant plus for eco-conscious users. The original scent is subtle, which may appeal to those sensitive to strong fragrances. However, the spray application method might require some physical effort, especially for larger areas.

The drying time is not explicitly mentioned, so it might vary depending on the surface and extent of the spill. The 32oz bottle size is practical for regular use, though some might find it slightly bulky for storage. If purchased directly from the authorized sellers, the satisfaction guarantee provides peace of mind, ensuring that users are protected if they are not fully satisfied with the product’s performance.

Rating
9.7
Chosen by1,273
Surface Compatibility
Scent

Most important from
119423 reviews

Surface Compatibility
I have also used it on just about every type of material; hardwood, wooden chests, carpet, clothing, couch fabric, cabinets, outside - none of the areas that I have used this cleaner on have stained or look any different condition wise than they looked before I used it!
Scent
The smell of the spray itself isn't offending at all either, it doesn't smell like chemicals at all and after a few hours you don't even notice that you even sprayed it - it just smells like your house again.
#2

Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies

Rating
9.4
Surface Compatibility
Scent
Application Method

Most important from
28531 reviews

Surface Compatibility
This enzyme cleaner smells like delicious citrus fruit and can be used on so many surfaces like carpet, floors, fabric, and furniture.
Scent
This enzyme cleaner smells like delicious citrus fruit and can be used on so many surfaces like carpet, floors, fabric, and furniture.
Application Method
It's incredibly easy to use: just twist the spray tip open, spray, wipe away, and let it dry.
Drying Time
It's incredibly easy to use: just twist the spray tip open, spray, wipe away, and let it dry.

The Angry Orange Stain Remover is a dual-action enzymatic cleaner specifically designed for pet stains and odors, making it ideal for dog owners dealing with urine, feces, and vomit. One of its major strengths is its ability to not just mask, but actually destroy odors and stains on contact, ensuring freshness for up to 80 hours. The cleaner's versatility is another strong point; it can be used on multiple surfaces, including carpets, hardwood floors, fabrics, and even turf, making it a convenient option for varied cleaning needs.

Its citrus scent, derived from natural enzymes and cold-pressed orange oils, leaves a pleasant fruity fragrance, which is safer for pets and children, provided it is not sprayed directly on them. The spray form makes application straightforward, although specific details about drying time are not provided in the product features. Additionally, the product's natural materials and the fact that it is made by Genesis BioSciences suggest a level of eco-friendliness, although direct claims about its environmental impact are not mentioned.

A minor drawback could be its origin from China, which might be a concern for those preferring locally-manufactured products. If there are any issues or concerns, the product offers customer support, which adds a layer of reliability. This product is especially suited for pet owners looking for an efficient, pleasant-smelling, multi-surface cleaner that tackles tough pet-related stains and odors effectively.

Rating
9.4
Surface Compatibility
Scent
Application Method

Most important from
28531 reviews

Surface Compatibility
This enzyme cleaner smells like delicious citrus fruit and can be used on so many surfaces like carpet, floors, fabric, and furniture.
Scent
This enzyme cleaner smells like delicious citrus fruit and can be used on so many surfaces like carpet, floors, fabric, and furniture.
Application Method
It's incredibly easy to use: just twist the spray tip open, spray, wipe away, and let it dry.
Drying Time
It's incredibly easy to use: just twist the spray tip open, spray, wipe away, and let it dry.
#3

Angry Orange Pet Odor Eliminator for Home - 8oz Dog and Cat Pee Smell Remover for Carpet, Grass, Tile and Furniture - Citrus Concentrate, Makes 128oz of Liquid

Rating
9.2
Surface Compatibility
Scent

Most important from
75528 reviews

Surface Compatibility
Used it on a couch that reeked of dog urine, and it not only eliminated the smell but also stopped the dog from peeing on the couch again.
Scent
The smell of cat pee brings severe anxiety, but Angry Orange made the entire house smell like oranges, completely masking the odor.

The Angry Orange Pet Odor Eliminator is designed to tackle strong pet urine odors, using enzymes to break down the smell at the source. This 8oz concentrate can make up to 128oz of cleaning solution, making it a cost-effective option for pet owners. The product is compatible with various surfaces including carpet, tile, wood, and grass, but is not suitable for leather.

It features a fresh citrus scent derived from orange peels, which leaves a pleasant smell in the home. Application is straightforward: mix the concentrate with water, shake, and spray. The product is manual, meaning no special equipment is necessary. One of its standout features is its eco-friendliness, as it uses natural oils and is pet-friendly.

Users should be aware that it may not be effective on all types of stains or surfaces and that the scent, while pleasant to some, might not be preferred by everyone. Additionally, drying time can vary depending on the surface and amount used. This cleaner is ideal for pet owners looking for an easy-to-use, versatile, and natural solution to manage pet odors.

Rating
9.2
Surface Compatibility
Scent

Most important from
75528 reviews

Surface Compatibility
Used it on a couch that reeked of dog urine, and it not only eliminated the smell but also stopped the dog from peeing on the couch again.
Scent
The smell of cat pee brings severe anxiety, but Angry Orange made the entire house smell like oranges, completely masking the odor.

Buying Guide for the Best Enzymatic Cleaners For Dog Urine

Choosing the right enzymatic cleaner for dog urine can make a significant difference in maintaining a clean and odor-free home. Enzymatic cleaners are specially formulated to break down the proteins in urine, eliminating both the stain and the odor at the source. When selecting an enzymatic cleaner, it's important to consider several key specifications to ensure you get the best product for your needs. Understanding these specifications will help you make an informed decision and keep your home fresh and clean.
Enzyme TypeEnzyme type refers to the specific enzymes used in the cleaner to break down urine proteins. This is important because different enzymes target different types of stains and odors. Common enzymes include proteases, amylases, and lipases. Proteases are effective for breaking down protein-based stains like urine, while amylases work on starches, and lipases target fats. For dog urine, a cleaner with proteases is typically the best choice. If you have multiple types of stains, a cleaner with a combination of enzymes may be more effective.
Surface CompatibilitySurface compatibility indicates which surfaces the cleaner can be safely used on. This is crucial because using the wrong cleaner on certain surfaces can cause damage. Enzymatic cleaners can be formulated for use on carpets, upholstery, hardwood floors, tile, and more. Check the product label to ensure it is safe for the surfaces you need to clean. If you have a variety of surfaces, look for a versatile cleaner that is safe for multiple types of materials.
ScentThe scent of an enzymatic cleaner can affect the overall freshness of your home. Some cleaners have a strong fragrance to mask odors, while others are unscented or have a mild scent. If you or your pets are sensitive to strong smells, an unscented or lightly scented cleaner may be preferable. On the other hand, if you want to add a pleasant fragrance to your home, a cleaner with a fresh scent might be a good choice. Consider your personal preference and any sensitivities when selecting a scent.
Application MethodThe application method refers to how the cleaner is applied to the affected area. Common methods include spray bottles, pour bottles, and foam applicators. This is important because the ease of application can affect how effectively you can treat the stain. Spray bottles are convenient for spot cleaning, while pour bottles may be better for larger areas. Foam applicators can help the cleaner penetrate deeper into carpets and upholstery. Choose an application method that suits the size and type of the stains you typically encounter.
Drying TimeDrying time is the amount of time it takes for the cleaner to dry after application. This is important because it affects how quickly you can use the cleaned area again. Some cleaners dry quickly, which is convenient for high-traffic areas, while others may take longer to fully dry. If you need to clean areas that are frequently used, a cleaner with a shorter drying time may be more practical. For deep cleaning, a longer drying time might be acceptable if it means more thorough stain removal.
Eco-FriendlinessEco-friendliness refers to the environmental impact of the cleaner. This is important for those who are concerned about the environment and want to use products that are safe for their pets and the planet. Eco-friendly cleaners are typically biodegradable, non-toxic, and free from harsh chemicals. If sustainability is a priority for you, look for products that are labeled as eco-friendly or have certifications from environmental organizations. These products are generally safer for your pets and the environment.

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