10 Best Cat Urine Cleaners With Enzymes 2025 in the United States

Nature's Miracle Urine Destroyer Plus for Cats is designed specifically to tackle severe cat urine stains using a strong enzymatic formula. This formula starts breaking down stains immediately and keeps working as long as any mess remains, which helps remove both stain and odor effectively. The product comes in a large, 1-gallon bottle that’s easy to pour, making it practical for refilling smaller spray containers.

It is safe to use around pets and in homes when instructions are followed, which is important for households with multiple animals or children. The scent is labeled as an odor remover, so it aims to neutralize smells rather than mask them with heavy fragrances, which many pet owners will appreciate.

The bottle size and weight might be a bit bulky for some users, and it doesn’t include a spray nozzle, so you’ll need a separate spray bottle for easy application. This cleaner is a solid choice for cat owners dealing with tough urine stains who want a trusted enzymatic solution that’s safe and effective without overpowering scents.

The Bioda Multi-Purpose Probiotic Enzyme Cleaner is designed as a professional-strength solution that uses probiotics, which act similarly to enzymes, to break down odors and stains. It is a versatile cleaner suitable for floors, bathrooms, drains, and trash cans, making it especially useful for pet owners dealing with cat urine and other organic messes. The lemon scent provides a fresh, clean smell that helps mask unpleasant odors without being overpowering. It comes in a 1-gallon liquid form, making it efficient for larger cleaning tasks.

While the product lists floors as a specific use, its broad description suggests it should be safe on various surfaces, though testing in a small area first is recommended. The packaging size and weight indicate that it’s a concentrated product likely requiring dilution. Being biobased and made in the USA, it offers a potentially safer and more environmentally friendly option compared to harsh chemical cleaners.

This cleaner is well-suited for pet owners seeking a multi-surface enzyme-based product with a pleasant scent and eco-conscious formulation. Users are encouraged to test its compatibility and application methods to meet their specific cleaning needs.

KINZUA ENVIRONMENTAL Urine B-Gone is a strong enzyme-based cleaner designed to tackle cat and dog urine stains and odors. It uses a high concentration of bacteria (200 billion microbe colonies) that break down urine and feces, targeting the root cause rather than just covering smells. This means it works deeply on carpets, upholstery, and even padding underneath, which is great if your pet has had accidents on soft surfaces. The product has a pleasant citrus scent, which leaves your home smelling fresh without being overpowering. You get a large 1-gallon size, making it suitable for frequent or heavy use.

It’s also versatile enough to be used on laundry and even in drains or toilets, so it’s not limited to just carpets. The liquid form is easy to apply, though drying times may vary depending on the surface and amount used, so patience is needed before the area is fully dry. Safety-wise, the formula is natural and safe for use around pets and children when directions are followed, which is reassuring for households with curious animals.

One downside is that the product is relatively heavy and bulky, which might be less convenient for quick spot cleaning or small spaces. Also, while the formula is strong, some users may find that very old or large stains require repeated applications to fully remove odors and marks. For those seeking a professional-strength cleaner that covers a variety of surfaces and uses a natural enzyme approach, Urine B-Gone balances power and safety well.